ENHANCEMENT OF ANTIBIOTIC ACTIVITY BY EFFLUX INHIBITORS AGAINST MULTIDRUG RESISTANT MYCOBACTERIUM TUBERCULOSIS CLINICAL ISOLATES FROM BRAZIL

Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil

Drug resistant tuberculosis continues to increase and new approaches for its treatment are necessary.The identification of M.tuberculosis clinical isolates presenting efflux as part of their resistant phenotype has a major impact in tuberculosis treatment.In this work, we used a checkerboard procedure combined with the tetrazolium microplate-based

read more

Fermentation of lactose to ethanol in cheese whey permeate and concentrated permeate by engineered Escherichia coli

Abstract Background Whey permeate is a lactose-rich effluent remaining after protein extraction from milk-resulting cheese whey, an abundant dairy waste.The lactose to ethanol fermentation can complete whey valorization chain by decreasing dairy waste polluting potential, due to its nutritional load, and producing a biofuel from renewable source at

read more

Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion

Astrocytic uptake of glutamate shapes extracellular neurotransmitter dynamics, receptor activation, and synaptogenesis.During development, glutamate transport becomes more robust.How neonatal brain insult affects the functional maturation of glutamate transport remains unanswered.Neonatal brain insult can napoleon concealer lead to developmental de

read more